科研成果
 
当前位置:首页  科研成果

2022

Zhang, Q., Wang, P., Wu, T., Zhang, Y.,  Zheng, Z., Zhou, S., Qian D., Wang, X*., Cai, G* .  Structures of Mec1/ATR Kinase Endogenously Stimulated by Different Genotoxins. Cell Discovery, Accepted.  


Li, P#., Xu, C#.,Zhang, X., Cao, C., Wang, X*., Cai, G*.Single-Stranded RNA Viruses Activate and Hijack Host Apical DNA Damage Response Kinases for Efficient Viral Replication. Genome Instability & Disease, 2022


2021


Wang, X., Dong, Y., Zhao, X., Li, J., Lee, J., Yan, Z., Yang, S., Wu, W., Hou, X., Liu, G., Zhang, Y., Song, L., Cai, G., Li, Q., Ira, G., Zhang, X*., Chen, X*. Rtt105 promotes high-fidelity DNA replication and repair by regulating the single-stranded DNA-binding factor RPA. Proc Natl Acad Sci U S A, 118(25):e2106393118, 2021


2020


Zhao, K., Wang, D., Zhao, X., Wang, C., Gao, Y., Liu, K., Wang, F., Wu. X., Wang, X., Sun L., Zang, J., Mei, Y*. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates p53 function in suppressing metastasis.EMBO Rep. 21(4): e49269, 2020


Li, L., Zhang, Z*. Recombinant expression and characterization of yeast Mrc1, a DNA replication checkpoint mediator. Prep Biochem Biotech 50: 198-203, 2020


2019

Xin, J#., Xu, Z#.,Wang, X#., Tian Y., Zhang, Z. and Cai, G*. Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Research 29655–665, 2019 (Cover story)

Shuwan Qiu#, Sheng Liu#, Zannati Ferdous Zaoti, Xuejuan Wang*, Gang Cai*. Modulation of Fatty Acid Synthase by ATR checkpoint kinase Rad3. Journal of Molecular Cell Biology 111098-1100, 2019

Wu, T., Zhang, Z., Wang, X*. Preparation of endogenous TopBP1/Dpb11 and effect on central checkpoint kinase Mec1- Ddc2 (human ATR-ATRIP homolog). Biochem. Biophys. Res. Commun 517291-296, 2019


2018


Wang, X*., Ahmad, S., Zhang, Z., CôtéJ., Cai, G*. Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications 9, 1147, 2018

Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. Architecture of SWI/SNF chromatin remodeling complex. Protein Cell 91045-1149, 2018

Zhang, X., Wang, X*., Zhang, Z. and Cai, G*. Structure and Functional Interactions of INO80 Actin/Arp Module. Journal of Molecular Cell Biology 11: 345-355, 2018 (Cover story)

Lan P, Tan M, Zhang Y, Niu S, Chen J, Shi S, Qiu S, Wang X, Peng X, Cai G, Cheng H, Wu J, Li G*, Lei M*. Structural insight into precursor tRNA processing by yeast ribonuclease P. Science 362: 6415, 2018


2017

Wang, X#., Ran, T#., Zhang,   X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science 3581206-1209, 2017

Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G*., and Sun, B.* AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. International Journal of Medical Microbiology 307: 257~267, 2017


2016

Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655, 2016

Jia, N., Liu, N., Cheng, W., Jiang, YL., Sun, H., Chen, L., Peng, J., Zhang, Y., Ding, Y., Zhang, Z., Wang, X., Cai, G., Wang, J., Dong, MQ., Zhang, Z., Wu, H., Wang, H*., Chen, Y*., and Zhou, C*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin‐like protein. EMBO Reports 17: 235~48, 2016


2015

Chen, P., Liu, Z., Wang, X., Sun, Q., Li, J., Wang, M., Niu, L., Cai, G*., Teng, M*., Li, X.* Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations. PLos One 10: e0120304, 2015


2014

Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G*. Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24796-808, 2014 (Cover story)

Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M*., and Li, X*. Crystal structure of DnaT84–153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res 42: 9470~9483, 2014

Zhao, D., Wang, X., Peng, J., Wang, C., Li, F., Sun, Q., Zhang, Y., Zhang, J., Cai, G., Zuo, X., Wu, J., Shi, Y., Gong, Q., and Zhang, Z*., Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin. Journal of Structural Biology 187: 194~205, 2014


2013

Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G*. Structural flexibility and functional interaction of mediator Cdk8 module. Protein & Cell 4: 911-920, 2013 (Cover story)


2012

Cai, G., Chaban, Y.L., Imasaki, T., Kovacs, J.A., Calero, G., Penczek, P.A., Takagi, Y., and Asturias, F.J.* Interaction of the mediator head module with RNA polymerase II. Structure 20: 899-910, 2012


2011

Imasaki, T., Calero, G., Cai, G., Tsai, K.L., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G.L., Asturias, F.J., Kornberg, R.D., Takagi, Y*. Architecture of the Mediator head module. Nature 475: 240-243, 2011

Chittuluru, J., Chaban, Y., Monnet-Saksouk, J., Carrozza, M., Sapountzi, S., Selleck, W., Huang, J., Utley, R., Cramet, M., Allard, S., Cai, G., Workman, J., Fried, J., Tan, S., Cote, J., and Asturias, F.* Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. Nature Structural & Molecular Biology 18: 1196~1203, 2011


Before 2010

Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y.*, and Asturias, F. * Mediator head module structure and functional interactions. Nature Structural & Molecular Biology 17: 273-279, 2010

Lee, J.,# Cai, G., # Panigrahi, A., Dunham-Ems, S., Nguyen, T., Radolf, J., Asturias, FJ., Gunzl, A.,* A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Molecular and Cellular Biology 30: 5502~5513, 2010

Cai, G., Imasaki, T., Takagi, Y., and Asturias, F.* Mediator structural conservation and implications for the regulation mechanism. Structure 17: 559-567, 2009 (Cover story)

蔡刚 单颗粒电子显微学的研究进展。生物物理学报 26: 560~569, 2010